My Raynaud's syndrome scares me, since it is not only very painful, your hands can become completely dysfunctional in a very short time.
I had a fairly new tire collapse and shred a few years ago. Evidently, it is not uncommon. I was very, very fortunate: I was on Interstate 8 in a semi-rural area not far from home around 10am on Saturday, with very light traffic.
My rule of thumb has always been that the hiking/climbing part of the trip should not be more dangerous than the driving. I was driving up Highway 74 this morning in the dark, on the way from Rancho Mirage to Idyllwild. There was a car lying on the side of the road, upside down, with the roof squashed. I had earlier seen what looked like the EMT's driving into Palm Desert, with flashing lights. But they were driving slowly, as though there was no hurry, which I thought was perhaps not a good sign for whoever they were taking in.